Rtog 0631 phase iiiii study of imageguided radiosurgery. The rtog 0631 phase 23 study comparing ssrs with conventional external beam radiation therapy excluded patients with epidural disease or mescc. Randomized phase ii trial evaluating pain response in patients with. Laack, ms, md this trial was conducted by the radiation therapy oncology group rtog, and. Conventional radiotherapy with of 110 fractions and total doses of 830 gy is the current standard for painful vertebral metastases. Standard single fraction 16 gy stereotactic imrt plans were generated for the same set of complex spinal lesions and used for. The phase ii component of rtog 0631 assessed the feasibility and.
The rtog 0225 and rtog 0615 protocols for npc provided good treatment outcomes and acceptable rtrelated toxicities in patients from the nonendemic regions 12. This trial was conducted by the radiation therapy oncology group rtog, and was supported by rtog grant u10 ca21661 and ccop grant u10 ca37422 from the national cancer institute nci. E4508, threearm randomized phase ii study of carboplatin and paclitaxel in combination with cetuximab, imc a12 or both for advanced nonsmall cell lung cancer patients who will not receive bevacizumab based therapy will be opened to the jkccn only. Physicians on this study were able to predict which patients would have longer survival times, although the prediction of survival was optimistic compared to actual survival by an average of 3. Current role of radiation therapy for multiple myeloma.
The oligometastatic state is hypothesized to represent an intermediary state of cancer between widely metastatic disease and curable, localized disease. The revised study design will test if the addition of androgen suppression to radiation therapy in patients with unfavorable pathologic stage pt3n0m0 prostate cancer leads to better overall survival than radiation therapy alone. Kps, fact scores, and physician predicted survival all are correlated with actual survival. Kane iii, md medical college of wisconsin roswell park cancer institute. Rtog is funded by national cancer institute grant numbers. A phase iii study comparing combined external beam radiation and transperineal interstitial permanent brachytherapy with brachytherapy alone for selected patients with intermediate risk prostatic carcinoma. Radiation therapy oncology group rtog 0618 a phase ii trial of stereotactic body radiation therapy sbrt in the treatment of. Longterm results of rtog 0236 confirm good primary tumor control, positive fiveyear survival rates. Standarddose versus highdose conformal radiotherapy with. Kachnic la1, winter k, myerson rj, goodyear md, willins j, esthappan j, haddock mg, rotman m, parikh pj, safran h, willett cg.
Numbers in the table represent the worst toxicity experienced by each patient when we used the radiation therapy oncology group rtog acute morbidity criteria for any reactions occurring within the first 90 days after starting radiation therapy acute toxicity and the rtog late morbidity criteria of any side effects occurring after 90 days. Advancements in radiotherapy have allowed for delivery of high precision, dose escalated treatment known as stereotactic body radiotherapy sbrt to targets throughout the body with excellent rates of local control. Rtog 0631 phase 23 study of image guided stereotactic radiosurgery for localized. The phase 2 component of radiation therapy oncology group rtog 0631 assessed the feasibility and safety of spine radiosurgery srs for localized spine metastases in a cooperative group setting. Cyberknife, international journal of radiation oncology biology physics on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. We aimed to compare overall survival after standarddose versus highdose conformal radiotherapy with concurrent chemotherapy and the addition of cetuximab to concurrent chemoradiation for patients with inoperable stage iii nonsmallcell lung cancer. Timely stereotactic body radiotherapy sbrt for spine. However, it is imperative to apply these protocols to patients from the areas of china where npc is endemic, and further assess longterm survival and late toxicities. Ryu and others published radiosurgery compared to external beam radiotherapy for localized spine metastasis. No other use or reproduction is authorized by rtog nor does rtog assume. Compliance rates for rtog 0631 need some improvement to ensure we can. We follow rtog 08 and rtog 0915 lung protocols criteria for ptv coverage, high dose spillage and dose fall off. A randomized, phase iii, doubleblind, placebocontrolled trial of memantine for prevention of cognitive dysfunction in patients receiving wholebrain radiotherapy nadia n.
Following on from the good results from the phase ii radiation therapy oncology group rtog 0631 trial which assessed the feasibility and safety of. In a randomized controlled trial conducted by the radiation therapy oncology group rtog 9714, the authors reported a significantly lower rate of acute toxicity after treatment with 8 gy in one fraction compared to 30 gy in 10 fractions. Rtog 0631 phase 23 study of image guided stereotactic. Imageguided radiosurgery or stereotactic body radiation therapy.
Request pdf rtog 0631 phase iiiii study of imageguided stereotactic radiosurgery for localized spine metastases. Volume 100, issue 4, 15 march 2018, pages 10671074. As in the previous report from the trial, which also. Rtog 0630 radiation therapy oncology group rtog 0630 a phase ii trial of image guided preoperative radiotherapy for primary soft tissue sarcomas of the extremity study chairs principal investigatorradiation oncology surgical oncology cochair dian wang, md, phd john m. Group rtog of the american college of radiology acr. Radiation therapy rt is a treatment modality traditionally used in patients with multiple myeloma mm, but little is known regarding the role and effectiveness of rt in the era of novel agents, i. A randomized trial of conventional fraction versus. This randomized trial demonstrates the utility of palliative sbrt for spinal metastases, which was.
As reported in the journal of clinical oncology by nguyentan et al, longterm followup in the phase iii radiation therapy oncology group rtog 0129 trial indicates no difference in overall survival or late toxicity with use of accelerated vs standard radiation therapy plus cisplatin in patients with locally advanced head and neck cancer. Phase iiiii study of imageguided radiosurgerysbrt for localized spine metastasis. The dosimetric impact of implants on the spinal cord dose. Phase iii randomized study of adjuvant therapy for high risk pt23n0 prostate cancer objective. As such, this clinical trial offers the first prospective data on the role of ssrs in a cohort of patients with more advanced epidural disease or frank mescc. Sites can download a copy of the protocol and the sample consent for irb. Rtog 0631 phase iiiii study of imageguided stereotactic. Rabinovitch r, moughan j, vicini f, pass h, wong j, chafe s, petersen i, arthur dw, white j. Stereotactic body radiotherapy sbrt is an emerging treatment option for spinal metastases with demonstrated efficacy in the upfront, postoperative, and retreatment settings, as well as for tumor histologies considered radioresistant. Radiosurgery compared to external beam radiotherapy for. Page 1 of 3 rtog 0631 phase iiiii study of imageguided radiosurgerysbrt for localized spine metastasis principal investigator. Rtog 0538calgb 30610 protocol student doctor network.
Schematic illustration of the phase 23 designed radiation therapy oncology group rtog 0631 study of spine. One third of all cancer patients will develop bone metastases and the vertebral column is involved in approximately 70% of these patients. Rtog 0631 phase 23 study of image guided stereotactic radiosurgery for localized spine metastases. The dose to the normal tissue was limited by considering the tolerance dose values as listed in table 2 which was adapted from rtog 0631. Assessment observation effects of radiotherapy on skin cells rationale rtog 0 no visible. Comparison of dose distribution in spine radiosurgery plans. Uncertainty exists regarding the optimal dose and fractionation schedule, with single and multifraction regimens commonly utilized.
Phase 1 study of spinal cord constraint relaxation with. International journal of radiation oncologybiologyphysics. The phase 2 component of radiation therapy oncology group rtog 0631 assessed the feasibility and safety of spine radiosurgery srs for localized spine. A phase iii comparison of thoracic radiotherapy regimens in patients with limited small cell lung cancer also receiving cisplatin and etoposide. Phase ii results of the rtog 0631 study showed stereotactic radiosurgery to be feasible and accurate 21. Improving quality and consistency in nrg oncology radiation therapy oncology group 0631 for spine radiosurgery via knowledgebased planning. Rtog 0631 radiation therapy oncology group rtog 0631 phase iiiii study of imageguided radiosurgerysbrt for localized spine metastasis study chairs principal investigatorradiation oncology samuel ryu, md henry ford hospital 2799 w. Broadcasts rtog clinical trials protocol table study details. Has the patient had prior pelvic radiation, prostate brachytherapy, bilateral orchiectomy, or cytotoxic. Rtog 4 ulceration, bleeding, necrosis rarely seen rtog assessment tool and intervention rationales please can you ensure that all patients on discharge are given one weeks supply of the dressings they are on. This site will allow users to register a patient or enter case form data directly to a nrgrtog study twentyfour 24 hours a day, seven 7 days a week. It is intended to be used only in conjunction with institutionspecific irb approval for study entry.
Rtog 0631 phase iiiii study of imageguided stereotactic radiosurgery for localized spine metastases. Read dosimetric comparison of single fraction sbrt for spinal metastases using linacbased imrt vs. Study protocol and statistical analysis plan pdf september 23, 2016. Trial rtog0926 a phase ii protocol for patients with stage t1 bladder cancer to evaluate selective bladder preserving treatment by radiation therapy concurrent with radiosensitizing chemotherapy following a thorough transurethral surgical restaging. Radiation therapy oncology group rtog 0241 phase i study of irinotecan and cisplatin in combination with twice daily thoracic radiotherapy 45 gy or once daily thoracic. Randomized trial of short versus longcourse radiotherapy. Radiation oncology the dosimetric impact of implants on the spinal cord dose during stereotactic body radiotherapy gozde yazici 0 sezin yuce sari 0 fazli yagiz yedekci 0 altug yucekul 1 sumerya duru birgi 0 gokhan demirkiran 1 melis gultekin 0 pervin hurmuz 0 muharrem yazici 1 gokhan ozyigit 0. Looks like it has been removed from the rtog website. Variability in spine radiosurgery treatment planning results of an.
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